For Mark and Debbe Russell. KRAM is MARK, reversed: a name carried backward so the work can move forward.
Kram is CHRONOS's public skin for Alzheimer's and dementia research: a fast-read state-of-the-field map, a falsifier ledger, and a triage bench for researchers who need to know where another hour of attention can actually move the terrain. It does not promise a cure. It makes the stuck places visible.
Ask Kram. Bring a paper, PMID/DOI, biomarker, trial result, SOTA claim, anecdote, or proposed experiment. Kram will return a research packet: what is known, what is missing, what would falsify it, and where a human researcher can spend energy.
Kram tracks dementia research as a falsifiable map: mechanisms, closure roles, empty cells, public predictions, and the experiment that could demote a favorite hypothesis.
For a researcher landing here: this is the quick map. Each lane names what Kram currently thinks the signal is, what it is watching, and the gap where competent effort has high marginal value.
The weak link is concrete. The ELISAs exist. Banked CSF exists. The experiment has not been done. That makes it the right public object for Kram to keep on the bench.
Active, contradicted, killed, watching: the board keeps research pressure visible. Kram does not reward attractive stories; it asks what would make them fail.
These are the live pressure points Kram wants a human researcher to see quickly: not broad topics, but questions whose answers would move, weaken, or retire claims.
A SOTA overview is useful only if it says what would change it. Kram keeps the predictions visible so future evidence can update the map without theater.
Costumed scalar, independent axis, candidate convergence node, meta-cost, or empty cell. No vague literature fog.
Raw, forensic-corrected, legitimacy estimate, and genuine lower bound stay distinct.
R5b perturb-and-polish cycles test whether the map survives pressure from nearby explanations.
Eight starred predictions keep thresholds visible so future evidence can move the map.
For Mark Russell, the namesake. For Debbe Russell, the road that brought us here. Kram exists so the next generation inherits a clearer map than the one this family was handed.