The field, in brief
Kram's read of the field loads from kram_terrain.json.
Kram · Alzheimer's research map
Kram turns a legacy into a research map.
For Mark and Debbe Russell. KRAM is MARK, reversed: a name carried backward so the work can move forward.
Kram maps Alzheimer's and dementia research. It shows what the field knows, where the gaps are, and which result would prove a favourite idea wrong. It does not promise a cure. It makes the stuck places visible.
MissionKram sorts Alzheimer's and dementia research. It shows where the field is stuck and which tests could change its mind.
Kram is a research map, not medical care. No medical advice, diagnosis, treatment guidance, prevention promise, cure promise, or invented citations.
If you have a health question, please see a doctor.
The workbench
One decisive question at a time
Kram keeps dementia research as a map that can be proven wrong: mechanisms, roles, empty cells, public bets, and the experiment that could demote a favourite idea.
Current decisive question
The current decisive question loads from kram_terrain.json.
Field overview · what Kram is tracking
The field is not one axis. Kram keeps the axes apart.
The quick map of the state of the art. Each lane says what Kram reads in the evidence, what it watches, and where careful work would count most.
The field map loads from kram_terrain.json.
Dynamic gap display · where time is valuable
Each gap is a question that could change the map
Not broad topics. Each one names the answer that would move, weaken or retire a claim.
The gap board loads from kram_terrain.json.
Falsifier scorecard
Public bets, public demotion rules
A map of the field is only useful if it says what would change it. Each bet names the result that would prove it wrong.
The scorecard loads from kram_terrain.json.
Claim lifecycle board
Claims move only when evidence moves
Active, watching, under audit: the board keeps the pressure visible. Kram does not reward attractive stories. It asks what would make them fail.
The claim board loads from kram_terrain.json.
Research streams
What Kram watches for
- StreamsThe list loads from kram_terrain.json.
Method
How Kram writes up a claim
Every claim on this page is broken into the same six parts, so a reader can see where the evidence is thin.
- boundary
Where medical care stops and the research map begins.
- terrain
The mechanism, cohort, assay and confound.
- evidence
What is supplied, and what still has to be sourced.
- uncertainty
Gaps, sources, and other explanations.
- falsifier
The result that would demote the claim.
- next step
One safe research step.
- Catalog
Every paper gets a role
Each paper is sorted into one role, such as a marker that only tracks severity, an independent axis, or a possible meeting point of causes. Empty cells are marked too.
- Audit
Rates stay apart
Raw rates, corrected rates, legitimacy estimates and lower bounds are reported side by side, never merged.
- Probe
Ideas get pushed
Kram checks whether the map still holds when nearby explanations push against it.
- Publish
Bets stay public
The starred predictions keep their thresholds in view, so new evidence can move the map.
Kram's audit
What Kram is allowed to claim
Kram is narrow on purpose. It can sort claims, show what would prove them wrong, keep sources visible, and call for decisive experiments. It cannot turn family urgency into certainty.
Open audit findings
- The audit findings load from kram_terrain.json.
Rate claims, figures and biomarker chains stay open to demotion until source scripts, assay metadata and four-number reports make them reproducible.
Boundaries
- The boundary list loads from kram_terrain.json.
For Mom and Dad
The work is on research timescales. The urgency is not.
For Mark Russell, the namesake. For Debbe Russell, the road that brought us here. Kram exists so the next generation inherits a clearer map than the one this family was handed.
Marknamesake
Kramthe workbench
Debbethe urgency
Mapthe promise kept honest
Kram does not provide medical advice, diagnosis, treatment guidance, or personal health recommendations. It is a public research instrument for evidence, falsifiers, and unanswered questions. The page is personal. The claims stay impersonal: no private data and no cure theatre.